The Database

DIT Drug Database (DDD) has its focus on helping physicians to identify and manage drug-drug interactions, allergies, duplicate therapies, side effects, contraindications and drug-disease interactions when prescribing. Pharmacy and consumer oriented systems are also supported and available on demand.

DDD is a comprehensive drug risk control system that provides reliable drug information based on literature research, manufacturer data, and information from the FDA and similar European authorities. It covers more than 180,000 commonly used over-the-counter and prescription drugs listed by NDCCODE and published with the NDCCODE by the FDA and contained in the RxNorm data set from the NIH.

The MDDI Calculator and the Revolution in drug risk checking

DDD with its MDDI Calculator, however, moves drug drug interaction checking in polypharmacy away from the traditional model towards Precision Medicine.

What is driving this REVOLUTION in drug risk checking which turns the world of drug interactions into a completely new one. The traditional model looks at drug interactions as a phenomena characterized by the relation of pairs of drugs. In poly-pharmaceutical scenarios this model produces frequent alerts. The user has then to puzzle together in a tedious and time consuming process what is important and what not, and what is really the compiled essence. Alert fatigue is a recurring unwanted consequence of long interaction listings as displayed below, too.

Therefore the “pair-of-drugs” model has been abandoned. This insight and new pharmacological knowledge resulted in modelling “MDDI” multi-drug-drug-interactions to give the user a tool to assess immediately the dose adjustment of the drugs most affected by multiple interaction mechanisms. Given a polypharmacy medication the simple question for each drug should be answered immediately: what is the impact of all the other drugs together on one drug, for example the impact on simvastatin or aripiprazole through bupropion, amlodipine, lorazepam, and clarithromycin?

The Precision Medicine Tool

On top of that the MDDI model is ready to take regard at the same time of the pharmacogenetics and the renal function of the patient with CKD. Therefore,with only a few clicks the personalized individual drug risk analysis in complex patient scenarios of polypharmacy with multiple drug drug interactions becomes possible and, therefore, DDD is more than a pure drug interaction checker, it is a Precision Medicine tool.

Webservice and Software Solutions

DDD comprises the Knowledge Engine with its clinical concepts and application software and interfaces for use in local networks, intranets and the worldwide web. DIT SQL Server solutions and Webservices with high performance server connections support also new EMR and e-prescribing cloud solutions.